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Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from (18)F-FDG PET brain persistent homology network

Dementia is related to the cellular accumulation of β-amyloid plaques, tau aggregates, or α-synuclein aggregates, or to neurotransmitter deficiencies in the dopaminergic and cholinergic pathways. Cellular and neurochemical changes are both involved in dementia pathology. However, the role of dopamin...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hsu, Tun-Wei, Fuh, Jong-Ling, Wang, Da-Wei, Chen, Li-Fen, Chang, Chia-Jung, Huang, Wen-Sheng, Wu, Hsiu-Mei, Guo, Wan-Yuo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940645/
https://ncbi.nlm.nih.gov/pubmed/33686089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84722-8
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