Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Surv...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Meiners, Annika, Bäcker, Sandra, Hadrović, Inesa, Heid, Christian, Beuck, Christine, Ruiz-Blanco, Yasser B., Mieres-Perez, Joel, Pörschke, Marius, Grad, Jean-Noël, Vallet, Cecilia, Hoffmann, Daniel, Bayer, Peter, Sánchez-García, Elsa, Schrader, Thomas, Knauer, Shirley K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940618/
https://ncbi.nlm.nih.gov/pubmed/33686072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21753-9
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