Increased transcription and high translation efficiency lead to accumulation of androgen receptor splice variant after androgen deprivation therapy

Upregulation of androgen receptor splice variants (AR-Vs), especially AR-V7, is associated with castration resistance of prostate cancer. At the RNA level, AR-V7 upregulation is generally coupled with increased full-length AR (AR-FL); consequently, AR-V7 and AR-Vs collectively constitute a minority...

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Udgivet i:Cancer Lett
Main Authors: Ma, Tianfang, Bai, Shanshan, Qi, Yanfeng, Zhan, Yang, Ungerleider, Nathan, Zhang, Derek Y., Neklesa, Taavi, Corey, Eva, Dehm, Scott M., Zhang, Kun, Flemington, Erik K., Dong, Yan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940584/
https://ncbi.nlm.nih.gov/pubmed/33556543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.12.037
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