Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias

Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system has been reported to analyze the pathology in humans. Here, we...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Pretemer, Yann, Kawai, Shunsuke, Nagata, Sanae, Nishio, Megumi, Watanabe, Makoto, Tamaki, Sakura, Alev, Cantas, Yamanaka, Yoshihiro, Xue, Jing-Yi, Wang, Zheng, Fukiage, Kenichi, Tsukanaka, Masako, Futami, Tohru, Ikegawa, Shiro, Toguchida, Junya
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940258/
https://ncbi.nlm.nih.gov/pubmed/33636111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.01.014
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