Endothelin-1 Upregulates Activin Receptor-Like Kinase-1 Expression via Gi/RhoA/Sp-1/Rho Kinase Pathways in Human Pulmonary Arterial Endothelial Cells

Background: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and organic stenosis. It has been demonstrated that endothelin-1 (ET-1) induces pulmonary vasoconstriction through the activation of RhoA. In addition, a gene mutation of activin receptor-like kinase (AC...

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Detalhes bibliográficos
Publicado no:Front Cardiovasc Med
Main Authors: Sugimoto, Koichi, Yokokawa, Tetsuro, Misaka, Tomofumi, Kaneshiro, Takashi, Yamada, Shinya, Yoshihisa, Akiomi, Nakazato, Kazuhiko, Takeishi, Yasuchika
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cardiovascular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940194/
https://ncbi.nlm.nih.gov/pubmed/33708809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.648981
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