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Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program
Methionine, through S-adenosylmethionine, activates a multifaceted growth program in which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription factor (called ATF4 in mammals), which facili...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7939465/ https://ncbi.nlm.nih.gov/pubmed/33122193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014248 |
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