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Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program
Methionine, through S-adenosylmethionine, activates a multifaceted growth program in which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription factor (called ATF4 in mammals), which facili...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7939465/ https://ncbi.nlm.nih.gov/pubmed/33122193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014248 |
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