Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions

Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell–mediated anti-tumor responses. Consequently, therapeutic blockade o...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Tocheva, Anna S., Peled, Michael, Strazza, Marianne, Adam, Kieran R., Lerrer, Shalom, Nayak, Shruti, Azoulay-Alfaguter, Inbar, Foster, Connor J.R., Philips, Elliot A., Neel, Benjamin G., Ueberheide, Beatrix, Mor, Adam
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939457/
https://ncbi.nlm.nih.gov/pubmed/33077516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014745
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