A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms

The dimeric ectonucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent suppressor of the immune response. Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor eradication and is a promising approach for cancer therapy....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Stefano, James E., Lord, Dana M., Zhou, Yanfeng, Jaworski, Julie, Hopke, Joern, Travaline, Tara, Zhang, Ningning, Wong, Karen, Lennon, Amanda, He, Timothy, Bric-Furlong, Eva, Cherrie, Cornishia, Magnay, Tristan, Remy, Elisabeth, Brondyk, William, Qiu, Huawei, Radošević, Katarina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2021
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939394/
https://ncbi.nlm.nih.gov/pubmed/33122192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012395
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