Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis

Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion pr...

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Vydáno v:PLoS Biol
Hlavní autoři: Niu, Mengmeng, He, Yajun, Xu, Jing, Ding, Liangping, He, Tao, Yi, Yong, Fu, Mengyuan, Guo, Rongtian, Li, Fengtian, Chen, Hu, Chen, Ye-Guang, Xiao, Zhi-Xiong Jim
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939357/
https://ncbi.nlm.nih.gov/pubmed/33626035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001113
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