Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

Preclinical studies show a link between subthalamic nucleus (STN) deep brain stimulation (DBS) and neuroprotection of nigrostriatal dopamine (DA) neurons, potentially through brain-derived neurotrophic factor (BDNF) signaling. However, the question of whether DBS of the STN can be disease-modifying...

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Pubblicato in:J Neurosci
Autori principali: Miller, Kathryn M., Patterson, Joseph R., Kochmanski, Joseph, Kemp, Christopher J., Stoll, Anna C., Onyekpe, Christopher U., Cole-Strauss, Allyson, Steece-Collier, Kathy, Howe, Jacob W., Luk, Kelvin C., Sortwell, Caryl E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939095/
https://ncbi.nlm.nih.gov/pubmed/33472823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1952-20.2020
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