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Method Development and Validation for Measuring O(6)-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry
BACKGROUND: Cyclophosphamide is a nitrogen mustard chemotherapy drug that damages DNA through alkylation in the DNA base and produces DNA adducts. Alkylation that occurs in the N7 position of guanine base has a cytotoxic effect which is useful for cancer therapy. However, the alkylation that occurs...
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| Опубликовано в: : | Drug Des Devel Ther |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Dove
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7937437/ https://ncbi.nlm.nih.gov/pubmed/33692614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S283775 |
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