Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

BACKGROUND: Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are thought to be an advantage as follow-up stud...

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Bibliografiske detaljer
Udgivet i:Genes Environ
Main Authors: Yasui, Manabu, Fukuda, Takayuki, Ukai, Akiko, Maniwa, Jiro, Imamura, Tadashi, Hashizume, Tsuneo, Yamamoto, Haruna, Shibuya, Kaori, Narumi, Kazunori, Fujiishi, Yohei, Okada, Emiko, Fujishima, Saori, Yamamoto, Mika, Otani, Naoko, Nakamura, Maki, Nishimura, Ryoichi, Ueda, Maya, Mishima, Masayuki, Matsuzaki, Kaori, Takeiri, Akira, Tanaka, Kenji, Okada, Yuki, Nakagawa, Munehiro, Hamada, Shuichi, Kajikawa, Akihiko, Honda, Hiroshi, Adachi, Jun, Misaki, Kentaro, Ogawa, Kumiko, Honma, Masamitsu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937321/
https://ncbi.nlm.nih.gov/pubmed/33676587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-021-00179-1
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