Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Zika virus has emerged as a potential threat to human health globally. A previous drug repurposing screen identified the approved anthelminthic drug niclosamide as a small molecule inhibitor of Zika virus infection. However, as antihelminthic drugs are generally designed to have low absorption when...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Shamim, Khalida, Xu, Miao, Hu, Xin, Lee, Emily M, Lu, Xiao, Huang, Ruili, Shah, Pranav, Xu, Xin, Chen, Catherine Z., Shen, Min, Guo, Hui, Chen, Lu, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Klumpp-Thomas, Carleen, Michael, Sam, Simeonov, Anton, Lo, Donald C., Ming, Guo-li, Song, Hongjun, Tang, Hengli, Zheng, Wei, Huang, Wenwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science Ltd 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936759/
https://ncbi.nlm.nih.gov/pubmed/33689873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.127906
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