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Zanubrutinib (BGB-3111), a Second-Generation Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase and Its Utility in Treating Chronic Lymphocytic Leukemia

The understanding of the B cell receptor (BCR) pathway and its contribution to chronic lymphocytic leukemia (CLL) pathogenesis have led to the development of targeted BCR inhibitors which have transformed the treatment paradigm of CLL. Ibrutinib is a first-in-class oral Bruton’s tyrosine kinase (BTK...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Rhodes, Joanna M, Mato, Anthony R
Format: Artigo
Jezik:Inglês
Izdano: Dove 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936706/
https://ncbi.nlm.nih.gov/pubmed/33688166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S250823
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