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Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy
Ciliary neurotrophic factor (CNTF) is a leading therapeutic candidate for several ocular diseases and induces optic nerve regeneration in animal models. Paradoxically, however, although CNTF gene therapy promotes extensive regeneration, recombinant CNTF (rCNTF) has little effect. Because intraocular...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7936361/ https://ncbi.nlm.nih.gov/pubmed/33627402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017282118 |
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