Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

Acute myocardial infarction is a common condition responsible for heart failure and sudden death. Here, we show that following acute myocardial infarction in mice, CD8(+) T lymphocytes are recruited and activated in the ischemic heart tissue and release Granzyme B, leading to cardiomyocyte apoptosis...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Santos-Zas, Icia, Lemarié, Jeremie, Zlatanova, Ivana, Cachanado, Marine, Seghezzi, Jean-Christophe, Benamer, Hakim, Goube, Pascal, Vandestienne, Marie, Cohen, Raphael, Ezzo, Maya, Duval, Vincent, Zhang, Yujiao, Su, Jin-Bo, Bizé, Alain, Sambin, Lucien, Bonnin, Philippe, Branchereau, Maxime, Heymes, Christophe, Tanchot, Corinne, Vilar, José, Delacroix, Clement, Hulot, Jean-Sebastien, Cochain, Clement, Bruneval, Patrick, Danchin, Nicolas, Tedgui, Alain, Mallat, Ziad, Simon, Tabassome, Ghaleh, Bijan, Silvestre, Jean-Sébastien, Ait-Oufella, Hafid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935973/
https://ncbi.nlm.nih.gov/pubmed/33674611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21737-9
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