Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

A major roadblock prohibiting effective cellular immunotherapy of pancreatic ductal adenocarcinoma (PDAC) is the lack of suitable tumor-specific antigens. To address this challenge, here we combine flow cytometry screenings, bioinformatic expression analyses and a cyclic immunofluorescence platform....

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Vydáno v:Nat Commun
Hlavní autoři: Schäfer, Daniel, Tomiuk, Stefan, Küster, Laura N., Rawashdeh, Wa’el Al, Henze, Janina, Tischler-Höhle, German, Agorku, David J., Brauner, Janina, Linnartz, Cathrin, Lock, Dominik, Kaiser, Andrew, Herbel, Christoph, Eckardt, Dominik, Lamorte, Melina, Lenhard, Dorothee, Schüler, Julia, Ströbel, Philipp, Missbach-Guentner, Jeannine, Pinkert-Leetsch, Diana, Alves, Frauke, Bosio, Andreas, Hardt, Olaf
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935963/
https://ncbi.nlm.nih.gov/pubmed/33674603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21774-4
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