RNA-seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia

Currently there is no consensus regarding the aetiology of the excessive ocular volume that characterizes high myopia. Thus, we aimed to test whether the gene pathways identified by gene set enrichment analysis of RNA-seq transcriptomics refutes the predictions of the Retinal Ion Driven Efflux (RIDE...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Vocale, Loretta Giummarra, Crewther, Sheila, Riddell, Nina, Hall, Nathan E., Murphy, Melanie, Crewther, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935918/
https://ncbi.nlm.nih.gov/pubmed/33674625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84338-y
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