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RNA-seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia

Currently there is no consensus regarding the aetiology of the excessive ocular volume that characterizes high myopia. Thus, we aimed to test whether the gene pathways identified by gene set enrichment analysis of RNA-seq transcriptomics refutes the predictions of the Retinal Ion Driven Efflux (RIDE...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vocale, Loretta Giummarra, Crewther, Sheila, Riddell, Nina, Hall, Nathan E., Murphy, Melanie, Crewther, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935918/
https://ncbi.nlm.nih.gov/pubmed/33674625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84338-y
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