Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell exhaustion linked to overall survival in 675 hepatocellular carcinoma (HCC) patients with diverse ethnicities and etiologies....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Hung, Man Hsin, Lee, Joo Sang, Ma, Chi, Diggs, Laurence P., Heinrich, Sophia, Chang, Ching Wen, Ma, Lichun, Forgues, Marshonna, Budhu, Anuradha, Chaisaingmongkol, Jittiporn, Ruchirawat, Mathuros, Ruppin, Eytan, Greten, Tim F., Wang, Xin Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935900/
https://ncbi.nlm.nih.gov/pubmed/33674593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21804-1
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