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Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

Neuroinflammation plays a crucial role during ageing and various neurological conditions, including Alzheimer's disease, multiple sclerosis and infection. Technical limitations, however, have prevented an integrative analysis of how lymphocyte immune receptor repertoires and their accompanying...

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Bibliografske podrobnosti
izdano v:Proc Biol Sci
Main Authors: Yermanos, Alexander, Neumeier, Daniel, Sandu, Ioana, Borsa, Mariana, Waindok, Ann Cathrin, Merkler, Doron, Oxenius, Annette, Reddy, Sai T.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934997/
https://ncbi.nlm.nih.gov/pubmed/33622131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2020.2793
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