The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling

The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF). Here, we investigate the function and chromatin structure of this –3 kb region and provide evidence that it functions as a classically de...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JCI Insight
Main Authors: Gally, Fabienne, Sasse, Sarah K., Kurche, Jonathan S., Gruca, Margaret A., Cardwell, Jonathan H., Okamoto, Tsukasa, Chu, Hong W., Hou, Xiaomeng, Poirion, Olivier B., Buchanan, Justin, Preissl, Sebastian, Ren, Bing, Colgan, Sean P., Dowell, Robin D., Yang, Ivana V., Schwartz, David A., Gerber, Anthony N.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934873/
https://ncbi.nlm.nih.gov/pubmed/33320836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144294
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