Trk agonist drugs rescue noise-induced hidden hearing loss

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro after synaptic loss due to kainic acid–induced glutamate tox...

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Udgivet i:JCI Insight
Main Authors: Fernandez, Katharine A., Watabe, Takahisa, Tong, Mingjie, Meng, Xiankai, Tani, Kohsuke, Kujawa, Sharon G., Edge, Albert S.B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934864/
https://ncbi.nlm.nih.gov/pubmed/33373328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142572
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