Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

A growing amount of evidence suggests that ubiquitination and deubiquitination of programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the regulation of PD-1 and PD-L1 protein stabilization and dynamics. PD-1/PD-L1 is a major coinhibitory checkpoint pathway that modulate...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Hu, Xiaoli, Wang, Jing, Chu, Man, Liu, Yi, Wang, Zhi-wei, Zhu, Xueqiong
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934629/
https://ncbi.nlm.nih.gov/pubmed/33388422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.032
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