Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

Vincristine is an important component of many regimens used for pediatric and adult malignancies, but it causes a dose-limiting sensorimotor neuropathy for which there is no effective treatment. This study aimed to delineate the neuro-inflammatory mechanisms contributing to the development of mechan...

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Publicat a:J Exp Med
Autors principals: Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate, Vetter, Irina
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933984/
https://ncbi.nlm.nih.gov/pubmed/33656514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201452
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