NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development

Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 complex to collaboratively promote rDNA transcription via triggering the directly binding of NF45/NF90 to the ARRE2‐like sequences in rDNA promoter upon T‐c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Mol Med
Prif Awduron: Tsai, Hsiang‐i, Zeng, Xiaobin, Liu, Longshan, Xin, Shengchang, Wu, Yingyi, Xu, Zhanxue, Zhang, Huanxi, Liu, Gan, Bi, Zirong, Su, Dandan, Yang, Min, Tao, Yijing, Wang, Changxi, Zhao, Jing, Eriksson, John E, Deng, Wenbin, Cheng, Fang, Chen, Hongbo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2021
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933818/
https://ncbi.nlm.nih.gov/pubmed/33555115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012834
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