Bioinformatic analysis of subfamily-specific regions in 3D-structures of homologs to study functional diversity and conformational plasticity in protein superfamilies

Local 3D-structural differences in homologous proteins contribute to functional diversity observed in a superfamily, but so far received little attention as bioinformatic analysis was usually carried out at the level of amino acid sequences. We have developed Zebra3D – the first-of-its-kind bioinfor...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Timonina, Daria, Sharapova, Yana, Švedas, Vytas, Suplatov, Dmitry
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933735/
https://ncbi.nlm.nih.gov/pubmed/33738079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.02.005
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