Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

Misuse of the psychostimulant methamphetamine (METH) could induce serious hepatotoxicity. Our previous study revealed the effects of luteolin on alleviating METH-induced hepatotoxicity, however, the detailed mechanisms have not been elucidated. In this study, rats were orally pretreated with 100 mg/...

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Publicat a:Front Pharmacol
Autors principals: Zhang, Kai-Kai, Wang, Hui, Qu, Dong, Chen, Li-Jian, Wang, Li-Bin, Li, Jia-Hao, Liu, Jia-Li, Xu, Ling-Ling, Yoshida, Jamie Still, Xu, Jing-Tao, Xie, Xiao-Li, Li, Dong-Ri
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933587/
https://ncbi.nlm.nih.gov/pubmed/33679421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.641917
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