Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts. They are widely used as hypoxia diagnostics and have also shown promise as...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Rashed, Faisal Bin, Stoica, Alexandru Cezar, MacDonald, Dawn, El-Saidi, Hassan, Ricardo, Carolynne, Bhatt, Bhumi, Moore, Jack, Diaz-Dussan, Diana, Ramamonjisoa, Nirilanto, Mowery, Yvonne, Damaraju, Sambasivarao, Fahlman, Richard, Kumar, Piyush, Weinfeld, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933538/
https://ncbi.nlm.nih.gov/pubmed/33640700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101905
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