Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways

Background and Objective: Diabetes mellitus (DM) is reportedly a significant risk factor for intervertebral disc degeneration (IDD). Incretin system and particularly glucagon-like peptide 1 (GLP-1) because of its glucose-lowering effects has become an important target in therapeutic strategies of ty...

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Detalhes bibliográficos
Publicado no:Front Med (Lausanne)
Main Authors: Yao, Mingyan, Zhang, Jing, Li, Zhihong, Bai, Xiaoliang, Ma, Jinhui, Li, Yukun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933515/
https://ncbi.nlm.nih.gov/pubmed/33681258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2021.630962
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