Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

BACKGROUND: Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate met...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Hoffmann, Markus, Hofmann-Winkler, Heike, Smith, Joan C., Krüger, Nadine, Arora, Prerna, Sørensen, Lambert K., Søgaard, Ole S., Hasselstrøm, Jørgen Bo, Winkler, Michael, Hempel, Tim, Raich, Lluís, Olsson, Simon, Danov, Olga, Jonigk, Danny, Yamazoe, Takashi, Yamatsuta, Katsura, Mizuno, Hirotaka, Ludwig, Stephan, Noé, Frank, Kjolby, Mads, Braun, Armin, Sheltzer, Jason M., Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930809/
https://ncbi.nlm.nih.gov/pubmed/33676899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103255
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