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The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1
Endoplasmic reticulum–associated degradation (ERAD) is a process directing misfolded proteins from the ER lumen and membrane to the degradation machinery in the cytosol. A key step in ERAD is the translocation of ER proteins to the cytosol. Derlins are essential for protein translocation in ERAD, bu...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7929502/ https://ncbi.nlm.nih.gov/pubmed/33658201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe8591 |
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