Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

The first reported receptor for SARS-CoV-2 on host cells was the angiotensin-converting enzyme 2 (ACE2). However, the viral spike protein also has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Moti...

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Publicado en:Sci Signal
Autores principales: Mészáros, Bálint, Sámano-Sánchez, Hugo, Alvarado-Valverde, Jesús, Čalyševa, Jelena, Martínez-Pérez, Elizabeth, Alves, Renato, Shields, Denis C., Kumar, Manjeet, Rippmann, Friedrich, Chemes, Lucía B., Gibson, Toby J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2021
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Research Resources
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928535/
https://ncbi.nlm.nih.gov/pubmed/33436497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abd0334
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