Molecular Evaluation of Fluoroquinolone Resistance in Serial Mycobacterium tuberculosis Isolates from Individuals Diagnosed with Multidrug-Resistant Tuberculosis

Fluoroquinolones (FQ) are crucial components of multidrug-resistant tuberculosis (MDR TB) treatment. Differing levels of resistance are associated with specific mutations within the quinolone-resistance-determining region (QRDR) of gyrA. We sequenced the QRDR from serial isolates of MDR TB patients...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Willby, Melisa, Chopra, Paige, Lemmer, Darrin, Klein, Katherine, Dalton, Tracy L., Engelthaler, David M., Cegielski, J. Peter, Posey, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927810/
https://ncbi.nlm.nih.gov/pubmed/33106264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01663-20
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