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Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy

BACKGROUND: In spite of disrupted repolarization of diabetic heart, some studies report less tendency of diabetic heart to develop ventricular arrhythmias suggesting effective compensatory mechanism. We hypothesized that myocardial alterations in HCN2 and HCN4 channels occur under hyperglycaemia. ME...

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Detalhes bibliográficos
Publicado no:BMC Cardiovasc Disord
Main Authors: Hadova, Katarina, Kralova, Eva, Doka, Gabriel, Bies Pivackova, Lenka, Kmecova, Zuzana, Krenek, Peter, Klimas, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927235/
https://ncbi.nlm.nih.gov/pubmed/33653265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12872-021-01929-3
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