SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

SLC45A2 encodes a putative transporter expressed primarily in pigment cells. SLC45A2 mutations cause oculocutaneous albinism type 4 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function, and regulation of SLC45A2 and its variants remain unknown. We show...

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Gepubliceerd in:Mol Biol Cell
Hoofdauteurs: Le, Linh, Escobar, Iliana E., Ho, Tina, Lefkovith, Ariel J., Latteri, Emily, Haltaufderhyde, Kirk D., Dennis, Megan K., Plowright, Lynn, Sviderskaya, Elena V., Bennett, Dorothy C., Oancea, Elena, Marks, Michael S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Cell Biology 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927184/
https://ncbi.nlm.nih.gov/pubmed/32966160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-03-0200
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