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A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

A major contributor to treatment failure in Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the drug-insensitivity of transiently dormant T. cruzi amastigotes. Here, we demonstrated that use of a currently available...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Bustamante, Juan M., Sanchez-Valdez, Fernando, Padilla, Angel M., White, Brooke, Wang, Wei, Tarleton, Rick L.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7926267/
https://ncbi.nlm.nih.gov/pubmed/33115952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb7656
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