A Prime/Boost Vaccine Regimen Alters the Rectal Microbiome and Impacts Immune Responses and Viremia Control Post-Simian Immunodeficiency Virus Infection in Male and Female Rhesus Macaques

An efficacious human immunodeficiency virus (HIV) vaccine will likely require induction of both mucosal and systemic immune responses. We compared the immunogenicity and protective efficacy of two mucosal/systemic vaccine regimens and investigated their effects on the rectal microbiome. Rhesus macaq...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Musich, Thomas, Thovarai, Vishal, Venzon, David J., Mohanram, Venkatramanan, Tuero, Iskra, Miller-Novak, Leia K., Helmold Hait, Sabrina, Rahman, Mohammad Arif, Hunegnaw, Ruth, Huiting, Erin, Yuan, Wuxing, O’hUigin, Colm, Hoang, Tanya, Sui, Yongjun, LaBranche, Celia, Montefiori, David, Bear, Jenifer, Rosati, Margherita, Bissa, Massimiliano, Berzofsky, Jay A., Pavlakis, George N., Felber, Barbara K., Franchini, Genoveffa, Robert-Guroff, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925174/
https://ncbi.nlm.nih.gov/pubmed/32967951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01225-20
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