Cellular Mechanism Underlying Highly-Active or Antiretroviral Therapy-Induced Lipodystrophy: Atazanavir, a Protease Inhibitor, Compromises Adipogenic Conversion of Adipose-Derived Stem/Progenitor Cells through Accelerating ER Stress-Mediated Cell Death in Differentiating Adipocytes

Lipodystrophy is a common complication in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) or antiretroviral therapy (ART). Previous studies demonstrated that endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) is invo...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Akita, Sadanori, Suzuki, Keiji, Yoshimoto, Hiroshi, Ohtsuru, Akira, Hirano, Akiyoshi, Yamashita, Shunichi
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924614/
https://ncbi.nlm.nih.gov/pubmed/33672735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22042114
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