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The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?

In this study, we assessed the potential use of the 1β-hydroxy-deoxycholic acid (1β-OH-DCA) to deoxycholic acid (DCA) urinary metabolic ratio (UMR) as a CYP3A metric in ten male healthy volunteers. Midazolam (MDZ) 1 mg was administered orally at three sessions: alone (control session), after pre-tre...

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Bibliografische gegevens
Gepubliceerd in:J Pers Med
Hoofdauteurs: Magliocco, Gaëlle, Desmeules, Jules, Bosilkovska, Marija, Thomas, Aurélien, Daali, Youssef
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923269/
https://ncbi.nlm.nih.gov/pubmed/33672438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11020150
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