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Identification and Characterization of Mortaparib(Plus)—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

SIMPLE SUMMARY: Functional inactivation of tumour suppressor protein p53 is frequently found in a large variety of cancers. One of the mechanisms by which p53 is inactivated is through its interaction with mortalin protein that inhibits its translocation, and hence the function, in the nucleus. Abro...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Sari, Anissa Nofita, Elwakeel, Ahmed, Dhanjal, Jaspreet Kaur, Kumar, Vipul, Sundar, Durai, Kaul, Sunil C., Wadhwa, Renu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921971/
https://ncbi.nlm.nih.gov/pubmed/33671256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040835
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