Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats

Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) proteins, on the development of hyperuricemic nephr...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Xiong, Chongxiang, Deng, Jin, Wang, Xin, Shao, Xiaofei, Zhou, Qin, Zou, Hequn, Zhuang, Shougang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921804/
https://ncbi.nlm.nih.gov/pubmed/33664670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.636154
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