White matter microstructure relates to motor outcomes in myotonic dystrophy type 1 independently of disease duration and genetic burden

Deficits in white matter (WM) integrity and motor symptoms are among the most robust and reproducible features of myotonic dystrophy type 1 (DM1). In the present study, we investigate whether WM integrity, obtained from diffusion-weighted MRI, corresponds to quantifiable motor outcomes (e.g., fine m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koscik, Timothy R., van der Plas, Ellen, Gutmann, Laurie, Cumming, Sarah A., Monckton, Darren G., Magnotta, Vincent, Shields, Richard K., Nopoulos, Peggy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921687/
https://ncbi.nlm.nih.gov/pubmed/33649422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84520-2
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