Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

Tau pathology in Alzheimer’s disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures of these...

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Publicado no:Sci Rep
Main Authors: Guennewig, Boris, Lim, Julia, Marshall, Lee, McCorkindale, Andrew N., Paasila, Patrick J., Patrick, Ellis, Kril, Jillian J., Halliday, Glenda M., Cooper, Antony A., Sutherland, Greg T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921390/
https://ncbi.nlm.nih.gov/pubmed/33649380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83872-z
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