Metabolic Modeling Combined With Machine Learning Integrates Longitudinal Data and Identifies the Origin of LXR-Induced Hepatic Steatosis

Temporal multi-omics data can provide information about the dynamics of disease development and therapeutic response. However, statistical analysis of high-dimensional time-series data is challenging. Here we develop a novel approach to model temporal metabolomic and transcriptomic data by combining...

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Bibliografische gegevens
Gepubliceerd in:Front Bioeng Biotechnol
Hoofdauteurs: van Riel, Natal A. W., Tiemann, Christian A., Hilbers, Peter A. J., Groen, Albert K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Bioengineering and Biotechnology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921164/
https://ncbi.nlm.nih.gov/pubmed/33665185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.536957
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