Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya

Patients following infection by chikungunya virus (CHIKV) can suffer for months to years from arthralgia and arthritis. Interestingly, methotrexate (MTX) a major immune-regulatory drug has proved to be of clinical benefit. We have previously shown that CHIKV can persist in the joint of one patient 1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Negl Trop Dis
Prif Awduron: Bedoui, Yosra, Septembre-Malaterre, Axelle, Giry, Claude, Jaffar-Bandjee, Marie-Christine, Selambarom, Jimmy, Guiraud, Pascale, Gasque, Philippe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920362/
https://ncbi.nlm.nih.gov/pubmed/33596205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009115
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