A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity

BACKGROUND: To understand the features of a replicating vaccine that might drive potent and durable immune responses to transgene-encoded antigens, we tested a replication-competent adenovirus type 4 encoding influenza virus H5 HA (Ad4-H5-Vtn) administered as an oral capsule or via tonsillar swab or...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Matsuda, Kenta, Migueles, Stephen A., Huang, Jinghe, Bolkhovitinov, Lyuba, Stuccio, Sarah, Griesman, Trevor, Pullano, Alyssa A., Kang, Byong H, Ishida, Elise, Zimmerman, Matthew, Kashyap, Neena, Martins, Kelly M., Stadlbauer, Daniel, Pederson, Jessica, Patamawenu, Andy, Wright, Nathaniel, Shofner, Tulley, Evans, Sean, Liang, C. Jason, Candia, Julián, Biancotto, Angelique, Fantoni, Giovanna, Poole, April, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Krammer, Florian, Connors, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919717/
https://ncbi.nlm.nih.gov/pubmed/33529172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140794
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