A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma

BACKGROUND: Cancer stem-like cells are a major cause of resistance to therapy in patients with glioblastoma (GBM) as well as other cancers. Tumor cells are maintained in a stem-like proliferative state in large part through the Notch signaling pathway. The function of this pathway in turn depends on...

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Опубликовано в: :Neurosurgery
Главные авторы: Peereboom, David M, Ye, Xiaobu, Mikkelsen, Tom, Lesser, Glenn J, Lieberman, Frank S, Robins, H Ian, Ahluwalia, Manmeet S, Sloan, Andrew E, Grossman, Stuart A
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Research—Human—Clinical Trials
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919338/
https://ncbi.nlm.nih.gov/pubmed/33027815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuros/nyaa412
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