Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis

Intronic hexanucleotide repeat expansions (HREs) in C9ORF72 are the most frequent genetic cause of amyotrophic lateral sclerosis, a devastating, incurable motoneuron (MN) disease. The mechanism by which HREs trigger pathogenesis remains elusive. The discovery of repeat-associated non-ATG (RAN) trans...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Pal, Arun, Kretner, Benedikt, Abo-Rady, Masin, Glaβ, Hannes, Dash, Banaja P, Naumann, Marcel, Japtok, Julia, Kreiter, Nicole, Dhingra, Ashutosh, Heutink, Peter, Böckers, Tobias M, Günther, René, Sterneckert, Jared, Hermann, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918691/
https://ncbi.nlm.nih.gov/pubmed/33619157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000764
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