Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch

IL-15 priming of NK cells is a broadly accepted concept, but the dynamics and underlying molecular mechanisms remain poorly understood. We show that as little as 5 min of IL-15 treatment in vitro, followed by removal of excess cytokines, results in a long-lasting, but reversible, augmentation of NK...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Luu, Thuy T, Schmied, Laurent, Nguyen, Ngoc-Anh, Wiel, Clotilde, Meinke, Stephan, Mohammad, Dara K, Bergö, Martin, Alici, Evren, Kadri, Nadir, Ganesan, Sridharan, Höglund, Petter
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2021
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918643/
https://ncbi.nlm.nih.gov/pubmed/33593878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000723
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