Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma

SIMPLE SUMMARY: Melanoma is the third most common cause of brain metastasis with a reported incidence of up to 80% leading to patients’ early mortality. Clinical activity at intracranial sites is often less and unsatisfactory when compared to extracranial metastases by using novel targeted or immune...

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Pubblicato in:Cancers (Basel)
Autori principali: Váraljai, Renáta, Horn, Susanne, Sucker, Antje, Piercianek, Daniela, Schmitt, Verena, Carpinteiro, Alexander, Becker, Katrin Anne, Reifenberger, Julia, Roesch, Alexander, Felsberg, Jörg, Reifenberger, Guido, Sure, Ulrich, Schadendorf, Dirk, Helfrich, Iris
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916600/
https://ncbi.nlm.nih.gov/pubmed/33578810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040731
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